INTRODUCTION: Venous thromboembolism (VTE) management increasingly involves anticoagulation with direct oral anticoagulants (DOACs). Few studies have used competing-risks analyses to ascertain the mortality-adjusted hemorrhage and recurrent VTE (rVTE) risk of individual DOACs. Furthermore, hemorrhage risk factors in patients treated with apixaban remain underexplored.MATERIALS AND METHODS: Patients diagnosed with VTE receiving anticoagulation were identified from the Optum Clinformatics Data Mart (2003-2019). Study endpoints included readmissions for intracranial hemorrhage (ICH), non-intracranial hemorrhage (non-ICH hemorrhage), and rVTE. Coarsened exact matching was used to balance baseline clinical characteristics. Complication incidence was evaluated using a competing-risks framework. We additionally modeled hemorrhage risk in apixaban-treated patients.RESULTS: Overall, 225,559 patients were included, of whom 34,201 received apixaban and 46,007 received rivaroxaban. Compared to rivaroxaban, apixaban was associated with decreased non-ICH hemorrhage (sHR=0.560, 95%CI=0.423-0.741), but not ICH, and rVTE (sHR=0.802, 95%CI=0.651-0.988) risk. This was primarily in emergent readmissions (sHR[emergent hemorrhage]=0.515, 95%CI=0.372-0.711; sHR[emergent rVTE]=0.636, 95%CI=0.488-0.830). Contributors to emergent hemorrhage in apixaban-treated patients include older age (sHR=1.025, 95%CI=1.011-1.039), female sex (sHR=1.662, 95%CI=1.252-2.207), prior prescription antiplatelet therapy (sHR=1.591, 95%CI=1.130-2.241), and complicated hypertension (sHR=1.936, 95%CI=1.134-3.307). Patients anticipated to be "high-risk" experienced elevated ICH (sHR=3.396, 95%CI=1.375-8.388) and non-ICH hemorrhage (sHR=3.683, 95%CI=2.957-4.588) incidence.CONCLUSIONS: In patients with VTE receiving anticoagulation, apixaban was associated with reduced non-ICH hemorrhage and rVTE risk, compared to rivaroxaban. Risk reduction was restricted to emergent readmissions. We present a risk-stratification approach to predict hemorrhage in patients receiving apixaban, potentially guiding future clinical decision-making.
View details for DOI 10.1016/j.thromres.2021.06.015
View details for PubMedID 34198049