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Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers. Scientific data Cohen-Adad, J., Alonso-Ortiz, E., Abramovic, M., Arneitz, C., Atcheson, N., Barlow, L., Barry, R. L., Barth, M., Battiston, M., Büchel, C., Budde, M., Callot, V., Combes, A. J., De Leener, B., Descoteaux, M., de Sousa, P. L., Dostál, M., Doyon, J., Dvorak, A., Eippert, F., Epperson, K. R., Epperson, K. S., Freund, P., Finsterbusch, J., Foias, A., Fratini, M., Fukunaga, I., Gandini Wheeler-Kingshott, C. A., Germani, G., Gilbert, G., Giove, F., Gros, C., Grussu, F., Hagiwara, A., Henry, P. G., Horák, T., Hori, M., Joers, J., Kamiya, K., Karbasforoushan, H., Kerkovský, M., Khatibi, A., Kim, J. W., Kinany, N., Kitzler, H. H., Kolind, S., Kong, Y., Kudlicka, P., Kuntke, P., Kurniawan, N. D., Kusmia, S., Labounek, R., Laganà, M. M., Laule, C., Law, C. S., Lenglet, C., Leutritz, T., Liu, Y., Llufriu, S., Mackey, S., Martinez-Heras, E., Mattera, L., Nestrasil, I., O'Grady, K. P., Papinutto, N., Papp, D., Pareto, D., Parrish, T. B., Pichiecchio, A., Prados, F., Rovira, À., Ruitenberg, M. J., Samson, R. S., Savini, G., Seif, M., Seifert, A. C., Smith, A. K., Smith, S. A., Smith, Z. A., Solana, E., Suzuki, Y., Tackley, G., Tinnermann, A., Valošek, J., Van De Ville, D., Yiannakas, M. C., Weber Ii, K. A., Weiskopf, N., Wise, R. G., Wyss, P. O., Xu, J. 2021; 8 (1): 219

Abstract

In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/ . The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.

View details for DOI 10.1038/s41597-021-00941-8

View details for PubMedID 34400655