Clonal hematopoiesis: from mechanisms to clinical intervention. Cancer discovery Kohnke, T., Majeti, R. 2021


Our knowledge of how clonal hematopoiesis (CH) relates to diverse health conditions has grown vastly over the past years, touching upon many specialties beyond cancer medicine. Given that CH can act as a precursor to overt disease in many settings, the promise of early intervention has garnered much attention. In this review, we discuss the state of CH research and outline the challenges in developing clinical trials of early interventions. We anticipate that incidental findings of CH will become more common in the near future, but evidence-based efforts of how to manage these findings is currently lacking.

View details for DOI 10.1158/2159-8290.CD-21-0901

View details for PubMedID 34407958