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Correcting the sex disparity in access to liver transplantation - Lest perfect be the enemy of better.

Correcting the sex disparity in access to liver transplantation - Lest perfect be the enemy of better. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Kwong, A. J., Lai, J. C., Kim, W. R. 2021

Abstract

The implementation of the Model for End-Stage Liver Disease (MELD) as the backbone of liver allocation policy in the United States in 2002 has overall improved waitlist outcomes and standardized access to liver transplantation for patients with end-stage liver disease. However, women experience higher waitlist mortality and lower transplant rates compared to men, attributed in part to underestimation of renal dysfunction by the use of serum creatinine in MELD and MELD-Na.1-3 Alternative models have been proposed to reduce this gap, including replacement of serum creatinine with estimated glomerular filtration rate or granting additional MELD points to women, but what has been lacking in the literature has been quantification and comparison of the potential impact of these models on the sex disparity itself.

View details for DOI 10.1111/ajt.16805

View details for PubMedID 34403193