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Comparative genomics of Enterobacter cloacae complex before and after acquired clinical resistance to Ceftazidime-Avibactam. Diagnostic microbiology and infectious disease Senchyna, F., Tamburini, F. B., Murugesan, K., Watz, N., Bhatt, A. S., Banaei, N. 2021; 101 (4): 115511

Abstract

Resistance to Ceftazidime-Avibactam in Enterobacter cloacae is poorly understood. Whole genome sequencing identified 6 variants in isolates collected from a patient before and after acquiring Ceftazidime-Avibactam resistance. This included a Phe396Leu mutation in acrB, a component of the AcrAB-TolC efflux pump, possibly mediating enhanced efflux of Ceftazidime and/ or Avibactam.

View details for DOI 10.1016/j.diagmicrobio.2021.115511

View details for PubMedID 34418822