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IgG4-related inflammatory pseudotumor of the central nervous system responsive to mycophenolate mofetil JOURNAL OF THE NEUROLOGICAL SCIENCES Moss, H. E., Mejico, L. J., de la Roza, G., Coyne, T. M., Galetta, S. L., Liu, G. T. 2012; 318 (1-2): 31-35

Abstract

Orbital apex and skull base masses often present with neuro-ophthalmic signs and symptoms. Though the localization of these syndromes and visualization of the responsible lesion on imaging is typically straightforward, definitive diagnosis usually relies on biopsy. Immunohistochemistry is important for categorization and treatment planning. IgG4-related disease is emerging as a pathologically defined inflammatory process that can occur in multiple organ systems. We present two patients with extensive inflammatory mass lesions of the central nervous system with immunohistochemistry positive for IgG4 and negative for ALK-1 as examples of meningeal based IgG4-related inflammatory pseudotumors. In both patients, there was treatment response to mycophenolate mofetil.

View details for DOI 10.1016/j.jns.2012.04.010

View details for Web of Science ID 000305668500004

View details for PubMedID 22546342

View details for PubMedCentralID PMC3366053