Association of human immunodeficiency virus infection with outcomes among adults hospitalized with COVID-19.

Abstract

OBJECTIVE: To evaluate the association of HIV infection with outcomes among people hospitalized with COVID-19.DESIGN: Prospectively-planned analysis of the American Heart Association's COVID-19 Cardiovascular Disease Registry.SETTING: 107 academic and community hospitals in the United States from March through December 2020.PARTICIPANTS: Consecutive sample of 21,528 adults hospitalized with COVID-19 at participating hospitals.MAIN OUTCOME AND MEASURE: Primary outcome was pre-defined as in-hospital mortality. We used hierarchical mixed effects models to assess the association of HIV with in-hospital mortality accounting for patient demographics, comorbidities and clustering by hospital. Secondary outcomes included major adverse cardiac events (MACE), severity of illness, and length of stay (LOS).RESULTS: The registry included 220 people living with HIV (PLWH). PLWH were younger and more likely to be male, Non-Hispanic Black, on Medicaid, and active tobacco users. Of the study population, 36 PLWH (16.4%) died compared with 3,290 (15.4%) without HIV (Risk ratio 1.06; 95%CI 0.79-1.43; p?=?0.71). After adjustment for age, sex, race, and insurance, HIV was not associated with in-hospital mortality (aOR 1.13; 95%CI 0.77-1.6; p?=?0.54) with no change in effect after adding body mass index and comorbidities (aOR 1.15; 95%CI 0.78-1.70; p?=?0.48). HIV was not associated with MACE (aOR 0.99; 95%CI 0.69-1.44, p?=?0.91), COVID severity (aOR 0.96; 95%CI 0.62-1.50; p?=?0.86), or LOS (aOR 1.03; 95% CI 0.76-1.66; p?=?0.21).CONCLUSIONS: In the largest study of PLWH hospitalized with COVID-19 in the United States to date, we did not find significant associations between HIV and adverse outcomes including in-hospital mortality, MACE, or severity of illness.

View details for DOI 10.1097/QAD.0000000000003129

View details for PubMedID 34750295