Abstract

Bronchopulmonary dysplasia is the most frequent adverse outcome of prematurity. Before implementation of antenatal steroids and surfactant therapy bronchopulmonary dysplasia was mostly characterized by fibrotic, scarred and hyper-inflated lungs due to pulmonary injury following mechanical ventilation and oxygen toxicity. With advances in neonatal medicine this "old" bronchopulmonary dysplasia has changed to a "new" bronchopulmonary dysplasia characterized by an arrest in lung growth, leading to alveolar simplification and pulmonary vascular dysangiogenesis. While the old definition was based on the need for oxygen supplementation at a postnatal age of 28 days or at a corrected gestational age of 36 weeks, the newer definition looks at the mode of respiratory support required (e.g., invasive versus non-invasive) and then graded as mild, moderate or severe. Patients with bronchopulmonary dysplasia may present with significantly impaired pulmonary function, reactive airways disease or exercise intolerance. Over time these patients may develop asthma or chronic obstructive pulmonary disease. The most serious long term complication is the development of pulmonary vascular disease and pulmonary hypertension. Medical treatment often includes diuretics, steroids, bronchodilators or oxygen supplementation and in the presence of pulmonary hypertension medication to decrease the pulmonary vascular resistance. Perioperative anesthetic risk is increased in children with pulmonary hypertension. These patients might require additional diagnostic imaging and plans for increased resource allocation such as post-operative intensive care admission.

View details for DOI 10.1111/pan.14365

View details for PubMedID 34877749