Bilateral Serpiginous-Like Chorioretinitis Associated with Ciliochoroidal Melanoma: A Clinicopathologic Correlation. Retina (Philadelphia, Pa.) Al-Moujahed, A., Lin, J. H., Gagnon, M. R., Pulido, J., Mruthyunjaya, P., Jung, J. J. 2022


PURPOSE: To report the clinicopathologic correlation of a case of bilateral serpiginous-like chorioretinitis (SLC) associated with unilateral ciliochoroidal melanoma.METHODS: A 71-year-old white female was diagnosed with progressive SLC in both eyes (OU) associated with ciliochoroidal melanoma in the right eye (OD). Clinical findings and imaging before and after enucleation OD were correlated to histologic and immunohistochemistry sections.RESULTS: Examination and imaging identified a peripheral bilobed amelanotic lesion with low reflectivity on B-scan ultrasound with an associated exudative detachment OD. Additionally, multiple areas of new SLC lesions in the macula and peripapillary region OD and along the inferior arcade in the left eye (OS) were observed. Oncologic evaluation confirmed a Class 2, ciliochoroidal melanoma, and the eye was enucleated. Autoimmune and infectious laboratory evaluation for the etiology of the SLC lesions were negative. Histopathology of the enucleated eye confirmed the diagnosis of uveal melanoma with lymphocytic inflammation at the edges of the tumor itself and in the areas of discrete SLC lesions. Immunohistochemistry identified similar predominantly cluster of differentiation (CD)3 and CD8 T-cells and fewer CD20 B-cells in both regions.CONCLUSION: Serpiginous-like chorioretinitis may present as a paraneoplastic, predominantly T-lymphocyte inflammation associated with intraocular tumor such as uveal melanoma.

View details for DOI 10.1097/IAE.0000000000003435

View details for PubMedID 35174798