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Comparative effectiveness of primary radiotherapy versus surgery in elderly patients with locally advanced oropharyngeal squamous cell carcinoma

Comparative effectiveness of primary radiotherapy versus surgery in elderly patients with locally advanced oropharyngeal squamous cell carcinoma ORAL ONCOLOGY Sher, D. J., Yan, J., Day, A., Sumer, B. D., Nhat-Long Pham, Khan, S., Zhu, H. 2019; 88: 18-26

Abstract

To determine the comparative effectiveness of primary radiotherapy (RT) and primary surgery (PS) for locally advanced oropharyngeal squamous cell carcinoma (OPSCC).Eligible individuals were patients in the SEER-Medicare registry diagnosed with locally advanced OPSCC between 2000 and 2011. Patients were categorized as receiving either primary RT?±?chemotherapy, or PS?±?adjuvant RT or chemoradiotherapy (CRT). Overall survival (OS) was analyzed using Cox multivariable analysis (MVA). Risks of gastrostomy dependence (GD), esophageal stricture (ES), and osteoradionecrosis (ORN) were analyzed using logistic regression.A total of 2754 patients (69% RT, 31% PS) were included in this cohort, with a median age of 72?years. Patients treated with RT, CRT and PS experienced 3-year OS outcomes of 36.1%, 52.8%, and 54.9%, respectively (p?

View details for DOI 10.1016/j.oraloncology.2018.11.004

View details for Web of Science ID 000454890700004

View details for PubMedID 30616791