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Improvement in the Detection of Locoregional Recurrence in Head and Neck Malignancies: F-18 Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Compared to High-Resolution Contrast-Enhanced Computed Tomography and Endoscopic Examination
Improvement in the Detection of Locoregional Recurrence in Head and Neck Malignancies: F-18 Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Compared to High-Resolution Contrast-Enhanced Computed Tomography and Endoscopic Examination LARYNGOSCOPE Rangaswamy, B., Fardanesh, M., Genden, E. M., Park, E. E., Fatterpekar, G., Patel, Z., Kim, J., Som, P. M., Kostakoglu, L. 2013; 123 (11): 2664-2669Abstract
To compare the diagnostic efficacy of positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG-PET)/computed tomography (CT) to that of contrast-enhanced high-resolution CT (HRCT) and assess the value of a combinatorial approach in detection of recurrent squamous cell cancer of the head and neck (HNC) and to assess the efficacy of FDG-PET/CT with and without HRCT in comparison to standard-of-care follow-up--physical examination (PE) and endoscopy (E)--in determination of locally recurrent HNC.Retrospective study.A total of 103 patients with HNC underwent FDG-PET/CT and neck HRCT. There were two groups of patients: Group A had an FDG-PET study acquired with low-dose CT, and group B had an FDG-PET study acquired with HRCT. The PET data obtained with or without HRCT were compared on a lesion and patient basis with the results of the PE/E.On a lesion basis, both groups combined had higher sensitivity and negative predictive value (NPV) than the HRCT. Specificity and positive predictive value (PPV) for group B were higher than for group A. On a patient basis, both groups combined had a higher sensitivity and NPV than PE/E, respectively, although specificity of PE/E was higher than that of either group. PET data obtained with either protocol directly influenced treatment.HRCT increases the specificity and PPV of PET/CT when acquired simultaneously with PET. FDG-PET/CT acquired with either LDCT or HRCT has higher accuracy than HRCT alone and increases the sensitivity and NPV of PE/E.
View details for DOI 10.1002/lary.24077
View details for Web of Science ID 000326231200027
View details for PubMedID 23553147