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Upregulation of retinal VEGF and connexin 43 in murine nonarteritic anterior ischemic optic neuropathy (NAION) induced with 577?nm laser. Experimental eye research Rangel, B., Mesentier-Louro, L. A., Lowe, L. L., Shariati, M. A., Dalal, R., Imventarza, J. A., Liao, Y. J. 2022: 109139

Abstract

Nonarteritic anterior ischemic optic neuropathy (NAION) is a common acute optic neuropathy and cause of irreversible vision loss in those older than 50 years of age. There is currently no effective treatment for NAION and yet the biological mechanisms leading to neuronal loss are not fully understood. Glial cells activation and intercommunication mediated by molecules such as gap junction protein Connexin 43 (Cx43) is thought to modulate neuronal fate in central nervous system disorders. In this study, we investigated retinal glial changes and neuronal loss following a novel NAION animal model using a 577?nm laser. We induced unilateral photochemical thrombosis using rose bengal at the optic nerve head vasculature in adult C57BL/6 mice using a 577?nm laser and performed morphometric analysis of the retinal structure using serial in vivo optical coherence tomography (OCT) and histology for glial and neuronal markers. OCT imaging revealed peripapillary thickening of the retinal ganglion cell complex (GCC, baseline: 79.5?±?1.0?mum, n?=?8; NAION: 93.0?±?2.5?mum, n?=?8, P?

View details for DOI 10.1016/j.exer.2022.109139

View details for PubMedID 35691373