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Changing Trends in Etiology-Based Hospitalizations with End-Stage Liver Disease in the United States from 2016 to 2019. Liver international : official journal of the International Association for the Study of the Liver Kim, D., Perumpail, B. J., Alshuwaykh, O., Dennis, B. B., Cholankeril, G., Ahmed, A. 2022

Abstract

BACKGROUNDS AND AIMS: A potent and safe antiviral agent may impact chronic hepatitis C (HCV)-related end-stage liver disease (ESLD). We assess etiology-based hospitalizations for ESLD in the United States, 2016-2019.METHODS: We utilized the National Inpatient Sample (NIS) from 2016 to 2019. We defined ESLD as either decompensated cirrhosis or hepatocellular carcinoma, criteria obtained from the International Classification of Diseases, Tenth Revision.RESULTS: National hospitalization rates for nonalcoholic fatty liver disease (NAFLD) increased significantly from 67.1/100,000 persons in 2016 to 93.6 in 2019 with an average annual percentage change (AAPC) of 12.1%, while chronic hepatitis C (HCV) decreased significantly from 71.2/100,000 persons in 2016 to 58.5 in 2019 (-6.5% AAPC). Hospitalizations for ESLD in alcohol-related liver disease (ALD) increased as well.CONCLUSIONS: Hospitalization rates for NAFLD-and ALD-related ESLD increased steadily, while those for HCV-related ESLD decreased during the direct-acting antivirals era.

View details for DOI 10.1111/liv.15381

View details for PubMedID 35906461