Changing Trends in Etiology-Based Hospitalizations with End-Stage Liver Disease in the United States from 2016 to 2019. Liver international : official journal of the International Association for the Study of the Liver Kim, D., Perumpail, B. J., Alshuwaykh, O., Dennis, B. B., Cholankeril, G., Ahmed, A. 2022


BACKGROUNDS AND AIMS: A potent and safe antiviral agent may impact chronic hepatitis C (HCV)-related end-stage liver disease (ESLD). We assess etiology-based hospitalizations for ESLD in the United States, 2016-2019.METHODS: We utilized the National Inpatient Sample (NIS) from 2016 to 2019. We defined ESLD as either decompensated cirrhosis or hepatocellular carcinoma, criteria obtained from the International Classification of Diseases, Tenth Revision.RESULTS: National hospitalization rates for nonalcoholic fatty liver disease (NAFLD) increased significantly from 67.1/100,000 persons in 2016 to 93.6 in 2019 with an average annual percentage change (AAPC) of 12.1%, while chronic hepatitis C (HCV) decreased significantly from 71.2/100,000 persons in 2016 to 58.5 in 2019 (-6.5% AAPC). Hospitalizations for ESLD in alcohol-related liver disease (ALD) increased as well.CONCLUSIONS: Hospitalization rates for NAFLD-and ALD-related ESLD increased steadily, while those for HCV-related ESLD decreased during the direct-acting antivirals era.

View details for DOI 10.1111/liv.15381

View details for PubMedID 35906461