Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN Haddad, R. I., Bischoff, L., Ball, D., Bernet, V., Blomain, E., Busaidy, N. L., Campbell, M., Dickson, P., Duh, Q., Ehya, H., Goldner, W. S., Guo, T., Haymart, M., Holt, S., Hunt, J. P., Iagaru, A., Kandeel, F., Lamonica, D. M., Mandel, S., Markovina, S., McIver, B., Raeburn, C. D., Rezaee, R., Ridge, J. A., Roth, M. Y., Scheri, R. P., Shah, J. P., Sipos, J. A., Sippel, R., Sturgeon, C., Wang, T. N., Wirth, L. J., Wong, R. J., Yeh, M., Cassara, C. J., Darlow, S. 2022; 20 (8): 925-951


Differentiated thyroid carcinomas is associated with an excellent prognosis. The treatment of choice for differentiated thyroid carcinoma is surgery, followed by radioactive iodine ablation (iodine-131) in select patients and thyroxine therapy in most patients. Surgery is also the main treatment for medullary thyroid carcinoma, and kinase inhibitors may be appropriate for select patients with recurrent or persistent disease that is not resectable. Anaplastic thyroid carcinoma is almost uniformly lethal, and iodine-131 imaging and radioactive iodine cannot be used. When systemic therapy is indicated, targeted therapy options are preferred. This article describes NCCN recommendations regarding management of medullary thyroid carcinoma and anaplastic thyroid carcinoma, and surgical management of differentiated thyroid carcinoma (papillary, follicular, Hurthle cell carcinoma).

View details for DOI 10.6004/jnccn.2022.0040

View details for PubMedID 35948029