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Osteoblast Lineage Support of Hematopoiesis in Health and Disease. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Kim, M. J., Valderrabano, R. J., Wu, J. Y. 2022

Abstract

In mammals, hematopoiesis migrates to the bone marrow during embryogenesis coincident with the appearance of mineralized bone, where hematopoietic stem cells (HSCs) and their progeny are maintained by the surrounding microenvironment or niche, and sustain the entirety of the hematopoietic system. Genetic manipulation of niche factors and advances in cell lineage tracing techniques have implicated cells of both hematopoietic and non-hematopoietic origin as important regulators of hematopoiesis in health and disease. Among them, cells of the osteoblast lineage, from stromal skeletal stem cell to matrix-embedded osteocyte, are vital niche residents with varying capacities for hematopoietic support depending on stage of differentiation. Here, we review populations of osteoblasts at differing stages of differentiation and summarize the current understanding of the role of the osteoblast lineage in supporting hematopoiesis. This article is protected by copyright. All rights reserved.

View details for DOI 10.1002/jbmr.4678

View details for PubMedID 35983701