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On-demand electrochemically controlled compound release from an ultrasonically powered implant. RSC advances Wang, M. L., Chamberlayne, C. F., Xu, H., Mofidfar, M., Baltsavias, S., Annes, J. P., Zare, R. N., Arbabian, A. 2022; 12 (36): 23337-23345

Abstract

On-demand drug delivery systems are promising for a wide range of therapeutic applications. When combined with wireless implants for controlled drug delivery, they can reduce overall dosage and side effects. Here, we demonstrate release of fluorescein from a novel on-demand release system for negatively charged compounds. The release system is based on a modified electroresponsive polypyrrole nanoparticulate film designed to minimize ion exchange with the stored compound - a major passive leakage mechanism. We further designed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. Release kinetics are characterized both in vitro and in vivo in mice using fluorescein as a model drug, demonstrating the feasibility of wireless, controllable drug release using an ultrasonically powered implant.

View details for DOI 10.1039/d2ra03422k

View details for PubMedID 36090393

View details for PubMedCentralID PMC9382542