Comorbidity defines risk of asthmatics for COVID-19 hospitalization: a global perspective. The Journal of allergy and clinical immunology Skevaki, C., Chinthrajah, R. S., Fomina, D., Rohde, G., Cao, S., He, Z., Serdotetskova, S., Seidemann, C., Grunewaldt, A., Vengadeswaran, A., Xie, M., Karsonova, A., Karaulov, A., Nadeau, K. C., Chung, H., Renz, H. 2022


BACKGROUND: The global epidemiology of asthma among COVID-19 patients presents striking geographic differences defining high and low [asthma and COVID-19] co-occurrence prevalence zones.OBJECTIVE: We aimed to compare asthma prevalence among hospitalized COVID-19 patients in major global hubs across the world with the application of common inclusion criteria and definitions.METHODS: We built a network of six academic hospitals in Stanford (Stanford University)/USA, Frankfurt (Goethe University), Giessen (Justus Liebig University) and Marburg (Philipps University)/Germany, and Moscow (Clinical Hospital 52 in collaboration with Sechenov University)/Russia. We collected clinical and laboratory data for patients hospitalized due to COVID-19.RESULTS: Asthmatics were overrepresented among hospitalized COVID-19 patients in Stanford and underrepresented in Moscow and Germany as compared to the prevalence among adults in the local community. Asthma prevalence was similar among ICU and hospital non-ICU patients, which implied that the risk for developing severe COVID-19 was not higher among asthmatics. The number of males and comorbidities was higher among COVID-19 patients in the Stanford cohort, and the most frequent comorbidities among these asthma patients were other chronic inflammatory airway disorders such as chronic obstructive pulmonary disease (COPD).CONCLUSION: Observed disparity in COVID-19-associated risk among asthmatics across countries and continents is connected to varying prevalence of underlying comorbidities, particularly COPD.CLINICAL IMPLICATION: Public health policies in the future will need to consider comorbidities with an emphasis on COPD for prioritization of vaccination and preemptive treatment.

View details for DOI 10.1016/j.jaci.2022.09.039

View details for PubMedID 36336123