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The IPTA Nashville consensus conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: II-consensus guidelines for prevention. Pediatric transplantation Green, M., Squires, J. E., Chinnock, R. E., Comoli, P., Danziger-Isakov, L., Dulek, D. E., Esquivel, C. O., Hocker, B., L'Huillier, A. G., Mazariegos, G. V., Visner, G. A., Bollard, C. M., Dipchand, A. I., Ferry, J. A., Gross, T. G., Hayashi, R., Maecker-Kolhoff, B., Marks, S., Martinez, O. M., Metes, D. M., Michaels, M. G., Preiksaitis, J., Smets, F., Swerdlow, S. H., Trappe, R. U., Wilkinson, J. D., Allen, U., Webber, S. A., Dharnidharka, V. R. 2022: e14350

Abstract

The International Pediatric Transplant Association (IPTA) convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post-transplant lymphoproliferative disorder after solid organ transplantation in children. In this report from the Prevention Working Group, we reviewed the existing literature regarding immunoprophylaxis and chemoprophylaxis, and pre-emptive strategies. While the group made a strong recommendation for pre-emptive reduction of immunosuppression at the time of EBV DNAemia (low to moderate evidence), no recommendations for use could be made for any prophylactic strategy or alternate pre-emptive strategy, largely due to insufficient or conflicting evidence. Current gaps and future research priorities are highlighted.

View details for DOI 10.1111/petr.14350

View details for PubMedID 36369745