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Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents. Frontiers in chemistry Martinez-Gualda, B., Graus, M., Camps, A., Vanhulle, E., Saul, S., Azari, S., Nhu Tran, D. H., Vangeel, L., Chiu, W., Neyts, J., Schols, D., Einav, S., Vermeire, K., De Jonghe, S. 2022; 10: 1058229

Abstract

RNA viral infections, including those caused by respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine encephalitis virus (VEEV), pose a major global health challenge. Here, we report the synthesis and screening of a series of pyrrolo[2,3-b]pyridines targeting RSV, SARS-CoV-2 and/or VEEV. From this campaign, a series of lead compounds was generated that demonstrated antiviral activity in the low single-digit micromolar range against the various viruses and did not show cytotoxicity. These findings highlight the potential of 3-alkynyl-5-aryl-7-aza-indoles as a promising chemotype for the development of broad-spectrum antiviral agents.

View details for DOI 10.3389/fchem.2022.1058229

View details for PubMedID 36385995