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Best clinical management of tenosynovial giant cell tumour (TGCT): A consensus paper from the community of experts. Cancer treatment reviews Silvia, S., Hans Roland, D., Inga-Marie, S., Klaus, W., Rick, H., Annalisa, T., Augusto, C., Jyoti, B., Giacomo Giulio, B., Nicholas, B., Jean-Yves, B., Kjetil, B., Javier-Martin, B., Wei-Wu Tom, C., Tos Paolo Angelo, D., Jayesh, D., Stephan, E., Mikael, E., Alessandro, G., Hans, G., Jendrik, H., Wolfgang, H., John, H., Antoine, I., Jones Robin, L., Akira, K., Andreas, L., Herbert, L., Eric, M., Carlo, M., Nadine, O., Emanuela, P., Shreyaskumar R, P., Peter, R., Brian, R., Piotr, R., Claudia, S., Kathrin, S., Seddon Beatrice, M., Morena, S., Staals Eric, L., William, T., Vanhoenacker Filip, M. M., Andrew, W., Lisette, W., Sydney, S., de Sande Michiel, V., Sebastian, B. 2022; 112: 102491

Abstract

Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive, mesenchymal tumor arising from the joints, bursa and tendon sheaths. TGCT comprises a nodular- and a diffuse-type, with the former exhibiting mostly indolent course and the latter a locally aggressive behavior. Although usually not life-threatening, TGCT may cause chronic pain and adversely impact function and quality of life (QoL). CSFR1 inhibitors are effective with benefit on symptoms and QoL but are not available in most countries. The degree of uncertainty in selecting the most appropriate therapy and the lack of guidelines on the clinical management of TGCT make the adoption of new treatments inconsistent across the world, with suboptimal outcomes for patients. A global consensus meeting was organized in June 2022, involving experts from several disciplines and patient representatives from SPAGN to define the best evidence-based practice for the optimal approach to TGCT and generate the recommendations presented herein.

View details for DOI 10.1016/j.ctrv.2022.102491

View details for PubMedID 36502615