Advances in co-opting anti-depressant drugs in glioma therapy. Cell reports. Medicine Pant, A., Lim, M. 2022; 3 (12): 100837


A study by Chryplewicz etal. demonstrated the efficacy of combining tricyclic antidepressant imipramine and anti-VEGF therapy in treating genetically engineered glioma models. Dual therapy synergistically improved vascular integrity, increased autophagy, and modulated the myeloid and lymphoid compartments in glioma.

View details for DOI 10.1016/j.xcrm.2022.100837

View details for PubMedID 36543105