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Longitudinal comparison of the developing gut virome in infants and their mothers.
Longitudinal comparison of the developing gut virome in infants and their mothers. Cell host & microbe Walters, W. A., Granados, A. C., Ley, C., Federman, S., Stryke, D., Santos, Y., Haggerty, T., Sotomayor-Gonzalez, A., Servellita, V., Ley, R. E., Parsonnet, J., Chiu, C. Y. 2023; 31 (2): 187Abstract
The human gut virome and its early life development are poorly understood. Prior studies have captured single-point assessments with the evolution of the infant virome remaining largely unexplored. We performed viral metagenomic sequencing on stool samples collected longitudinally from a cohort of 53 infants from age 2weeks to 3 years (80.7 billion reads), and from their mothers (9.8 billion reads) to examine and compare viromes. The asymptomatic infant virome consisted of bacteriophages, nonhuman dietary/environmental viruses, and human-host viruses, predominantly picornaviruses. In contrast, human-host viruses were largely absent from the maternal virome. Previously undescribed, sequence-divergent vertebrate viruses were detected in the maternal but not infant virome. As infants aged, the phage component evolved to resemble the maternal virome, but by age 3, the human-host component remained dissimilar from the maternal virome. Thus, early life virome development is determined predominantly by dietary, infectious, and environmental factors rather than direct maternal acquisition.
View details for DOI 10.1016/j.chom.2023.01.003
View details for PubMedID 36758519