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Role of Dermal-Epidermal Basement Membrane Zone in Skin, Cancer, and Developmental Disorders

Role of Dermal-Epidermal Basement Membrane Zone in Skin, Cancer, and Developmental Disorders DERMATOLOGIC CLINICS Ko, M. S., Marinkovich, M. P. 2010; 28 (1): 1-?

Abstract

The dermal-epidermal basement membrane zone is an important epithelial and stromal interface, consisting of an intricately organized collection of intracellular, transmembrane, and extracellular matrix proteins. The basement membrane zone has several main functions including acting as a permeability barrier, forming an adhesive interface between epithelial cells and the underlying matrix, and controlling cellular organization and differentiation. This article identifies key molecular players of the dermal-epidermal membrane zone, and highlights recent research studies that have identified structural and functional roles of these components in the context of various blistering, neoplastic, and developmental syndromes.

View details for DOI 10.1016/j.det.2009.10.001

View details for PubMedID 19945611