Long-term quality of life after treatment in sinonasal malignancy: A prospective, multi-center study. International forum of allergy & rhinology Maoz, S. L., Wang, E. W., Hwang, P. H., Choby, G., Kuan, E. C., Fleseriu, C. M., Chan, E. P., Adappa, N. D., Geltzeiler, M., Getz, A. E., Humphreys, I. M., Le, C. H., Abuzeid, W. M., Chang, E. H., Jafari, A., Kingdom, T. T., Kohanski, M. A., Lee, J. K., Lazor, J. W., Nabavizadeh, A., Nayak, J. V., Palmer, J. N., Patel, Z. M., Pinheiro-Neto, C. D., Resnick, A. C., Smith, T. L., Snyderman, C. H., St John, M. A., Storm, P. B., Suh, J. D., Wang, M. B., Sim, M. S., Beswick, D. M. 2023


Quality-of-life (QOL) for individuals with sinonasal malignancy (SNM) is significantly understudied yet critical for counseling and may impact treatment. This study evaluated the how patient, treatment, and disease factors impact sinonasal-specific and generalized QOL using validated metrics in a large cohort over a 5-year post-treatment timeframe.Patients with SNM who underwent definitive treatment with curative intent were enrolled into a prospective, multi-site, longitudinal observational study. QOL was assessed using the Sinonasal Outcome Test-22 (SNOT-22) and University of Washington Quality of Life Questionnaire (UWQOL) instruments at pre-treatment baseline and multiple follow-ups through 5 years post-treatment. Multivariable modelling was used to determine demographic, disease, and treatment factors associated with disease-specific and generalized physical and social/emotional function QOL.194 patients with SNM were analyzed. All QOL indices were impaired at pre-treatment baseline and improved post-treatment. SNOT-22 scores improved 3 months and UWQOL scores improved 6-9 months post-treatment. Patients who underwent open compared to endoscopic tumor resection had worse generalized QOL (p<0.001), adjusted for factors including T stage. Pterygopalatine fossa (PPF) involvement was associated with worse QOL (SNOT-22, p<0.001; UWQOL-Physical, p = 0.02). Adjuvant radiation was associated with worse disease-specific QOL (p = 0.03). Neck dissection was associated with worse generalized physical function QOL (p = 0.01). Positive margins were associated with worse generalized social/emotional function QOL (p = 0.01).Disease-specific and generalized QOL is impaired at baseline in patients with SNM and improves following treatment. Endoscopic resection is associated with better QOL. PPF involvement, adjuvant radiation, neck dissection, and positive margins were associated with worse QOL post-treatment. This article is protected by copyright. All rights reserved.

View details for DOI 10.1002/alr.23171

View details for PubMedID 37082883