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Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society Ryman, S. G., Shaff, N., Dodd, A., Nitschke, S., Wertz, C., Julio, K., Suarez Cedeno, G., Deligtisch, A., Erhardt, E., Lin, H., Vakhtin, A., Poston, K. L., Tarawneh, R., Pirio Richardson, S., Mayer, A. 2023

Abstract

Cerebrovascular dysfunction in Parkinson's disease (PD) is heterogeneous and may contribute to disease pathophysiology or progression. There is a need to understand the mechanisms by which cerebrovascular dysfunction is altered in participants with PD.The objective of this study is to test the hypothesis that participants with PD exhibit a significant reduction in the ability of the cerebral vessels to dilate in response to vasoactive challenges relative to healthy controls (HC).The current study uses a vasodilatory challenge while participants undergo functional magnetic resonance imaging to quantify the amplitude and delay of cerebrovascular reactivity in participants with PD relative to age and sex-matched HC. An analysis of covariance was used to evaluate differences in cerebrovascular reactivity amplitude and latency between PD participants and HC.A significant main effect of group was observed for whole-brain cerebrovascular reactivity amplitude (F(1, 28) ?=?4.38, p?=?0.046, Hedge's g?=?0.73) and latency (F(1, 28) ?=?16.35, p?

View details for DOI 10.1002/mds.29429

View details for PubMedID 37157056