OBJECTIVE: Thyroid cancer incidence has increased significantly in recent decades. While most thyroid cancers are small and carry an excellent prognosis, a subset of patients present with advanced thyroid cancer which is associated with increased rates of morbidity and mortality. Management of thyroid cancer requires a thoughtful individualized approach in order to optimize oncologic outcomes and minimize morbidity associated with treatment. Since endocrinologists usually play a key role in the initial diagnosis and evaluation of thyroid cancers, a thorough understanding of the critical components of the preoperative evaluation facilitates the development of a timely and comprehensive management plan. The following review outlines considerations in the preoperative evaluation of patients with thyroid cancer.METHODS: A clinical review based on current literature was generated by a multidisciplinary author panel.RESULTS: A review of considerations in the preoperative evaluation of thyroid cancer is provided. Topic areas include initial clinical evaluation, imaging modalities, cytologic evaluation, and the evolving role of mutational testing. Special considerations in the management of advanced thyroid cancer are discussed.CONCLUSIONS: Thorough and thoughtful preoperative evaluation is critical to formulating an appropriate treatment strategy in the management of thyroid cancer.
View details for DOI 10.1016/j.eprac.2023.05.009
View details for PubMedID 37236353