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The negative effect of aging on cerebral venous outflow in acute ischemic stroke.
The negative effect of aging on cerebral venous outflow in acute ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Heitkamp, C., Winkelmeier, L., Heit, J. J., Flottmann, F., Thaler, C., Kniep, H., Broocks, G., Meyer, L., Geest, V., Albers, G. W., Lansberg, M. G., Fiehler, J., Faizy, T. D. 2023: 271678X231179558Abstract
Cortical venous outflow (VO) represents an imaging biomarker of increasing interest in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). We conducted a retrospective multicenter cohort study to investigate the effect of aging on VO. A total of 784 patients met the inclusion criteria. Cortical Vein Opacification Score (COVES) was used to assess VO profiles on admission CT angiography. Cerebral microperfusion was determined using the hypoperfusion intensity ratio (HIR) derived from perfusion imaging. Arterial collaterals were assessed using the Tan scale. Multivariable regression analysis was performed to identify independent determinants of VO, HIR and arterial collaterals. In multivariable regression, higher age correlated with worse VO (adjusted odds ratio [95% CI]; 0.83 [0.73-0.95]; P?=?0.006) and poorer HIR (ß coefficient [95% CI], 0.014 [0.005-0.024]; P?=?0.002). The negative effect of higher age on VO was mediated by the extent of HIR (17.3%). We conclude that higher age was associated with worse VO in AIS-LVO, partially explained by the extent of HIR reflecting cerebral microperfusion. Our study underlines the need to assess collateral blood flow beyond the arterial system and provides valuable insights into deteriorated cerebral blood supply in elderly AIS-LVO patients.
View details for DOI 10.1177/0271678X231179558
View details for PubMedID 37254736