Abstract

Myopia is a known risk factor for rhegmatogenous retinal detachment (RRD). Given global trends of increasing myopia, we aimed to determine the absolute risk (incidence rate) of RRD in non-myopes, myopes and high myopes in the United States over ten years. We performed a retrospective cohort study of 85,476,781 commercially insured patients enrolled in the Merative Marketscan Research Database. The incidence rate of RRD in phakic patients inthe United States was 39-fold higher in high myopes than non-myopes (868.83 per 100,000 person-years versus 22.44 per 100,000 person-years)and three-fold higher in myopes than non-myopes (67.51 per 100,000 person-yearsversus22.44 per 100,000 person-years). The incidence rate was significantly higher in males in each category (P<0.01). Combined, the incidence rate of RRD in phakic patients inthe United States from 2007 to 2016was 25.27 RRDs per 100,000 person-years, a rate higherthan those in prior published studies in North America, South America, Europe, Asia, and Australia.The absolute risk of myopia and high myopia increased from 2007 to 2016. Therisk of RRD in phakichigh myopes rosewith increasing age. Notably, the magnitude of increased risk of RRD in myopes varied substantially according to the minimum follow-up period in our models and should be accounted for when interpreting data analyses.

View details for DOI 10.1038/s41598-023-35520-x

View details for PubMedID 37296124