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Translational Models in Glioma Immunotherapy Research.

Translational Models in Glioma Immunotherapy Research. Current oncology (Toronto, Ont.) Ren, A. L., Wu, J. Y., Lee, S. Y., Lim, M. 2023; 30 (6): 5704-5718

Abstract

Immunotherapy is a promising therapeutic domain for the treatment of gliomas. However, clinical trials of various immunotherapeutic modalities have not yielded significant improvements in patient survival. Preclinical models for glioma research should faithfully represent clinically observed features regarding glioma behavior, mutational load, tumor interactions with stromal cells, and immunosuppressive mechanisms. In this review, we dive into the common preclinical models used in glioma immunology, discuss their advantages and disadvantages, and highlight examples of their utilization in translational research.

View details for DOI 10.3390/curroncol30060428

View details for PubMedID 37366911