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Viral Hepatitis and Acute-on-Chronic Liver Failure. Clinics in liver disease Bhatti, T. K., Singal, A. K., Kwo, P. Y. 2023; 27 (3): 617-630

Abstract

Acute-on-chronic liver failure (ACLF) is a potentially reversible syndrome that develops in patients with cirrhosis or with underlying chronic liver disease (CLD) and is characterized by acute decompensation, organ failure, and high short-term mortality. Hepatitis A and hepatitis E are major causes of ACLF. Hepatitis B may also cause ACLF through a flare of hepatitis B, acute infection, or reactivation. Besides supportive care, nucleoside/nucleotide analog therapy should also be initiated in this setting. Nonhepatotropic viruses may rarely also cause ACLF with the severe acute respiratory syndrome coronavirus 2 virus recently being identified with poorer outcomes in those with underlying CLD.

View details for DOI 10.1016/j.cld.2023.03.006

View details for PubMedID 37380286