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The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Limoli, C. L., Kramár, E. A., Almeida, A., Petit, B., Grilj, V., Baulch, J. E., Ballesteros-Zebadua, P., Loo, B. W., Wood, M. A., Vozenin, M. C. 2023: 109767

Abstract

Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3Gy (30Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.

View details for DOI 10.1016/j.radonc.2023.109767

View details for PubMedID 37385377