Case Report: Relapsing Leptospirosis in an Immunocompromised Host. The American journal of tropical medicine and hygiene Prasad, R., Narsana, N. K., Ajayi, A. A., Wang, H., Patel, J., Ho, D. Y., Banaei, N., Blackburn, B. G. 2023


Leptospirosis is typically a self-limited febrile illness; when it occurs, meningitis usually develops early in the course. Here, we describe a patient who had engaged in freshwater activities in Kauai that was immunocompromised due to a history of mantle cell lymphoma, autologous hematopoietic cell transplant, and hypogammaglobulinemia. He developed leptospiral meningoencephalitis 11 weeks after illness onset and persistently detectable Leptospira DNA in blood and cerebrospinal fluid along with ongoing clinical illness, despite appropriate treatment.

View details for DOI 10.4269/ajtmh.23-0111

View details for PubMedID 37604468