Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS). Blood reviews Stahl, M., Bewersdorf, J. P., Xie, Z., Porta, M. G., Komrokji, R., Xu, M. L., Abdel-Wahab, O., Taylor, J., Steensma, D. P., Starczynowski, D. T., Sekeres, M. A., Sanz, G., Sallman, D. A., Roboz, G. J., Platzbecker, U., Patnaik, M. M., Padron, E., Odenike, O., Nimer, S. D., Nazha, A., Majeti, R., Loghavi, S., Little, R. F., List, A. F., Kim, T. K., Hourigan, C. S., Hasserjian, R. P., Halene, S., Griffiths, E. A., Gore, S. D., Greenberg, P., Figueroa, M. E., Fenaux, P., Efficace, F., DeZern, A. E., Daver, N. G., Churpek, J. E., Carraway, H. E., Buckstein, R., Brunner, A. M., Boultwood, J., Borate, U., Bejar, R., Bennett, J. M., Wei, A. H., Santini, V., Savona, M. R., Zeidan, A. M. 2023: 101128

Abstract

The guidelines for classification, prognostication, and response assessment of myelodysplastic syndromes/neoplasms (MDS) have all recently been updated. In this report on behalf of the International Consortium for MDS (icMDS) we summarize these developments. We first critically examine the updated World Health Organization (WHO) classification and the International Consensus Classification (ICC) of MDS. We then compare traditional and molecularly based risk MDS risk assessment tools. Lastly, we discuss limitations of criteria in measuring therapeutic benefit and highlight how the International Working Group (IWG) 2018 and 2023 response criteria addressed these deficiencies and are endorsed by the icMDS. We also address the importance of patient centered care by discussing the value of quality-of-life assessment. We hope that the reader of this review will have a better understanding of how to classify MDS, predict clinical outcomes and evaluate therapeutic outcomes.

View details for DOI 10.1016/j.blre.2023.101128

View details for PubMedID 37704469