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The role of multiple sclerosis subtype in microvascular decompression outcomes for patients with trigeminal neuralgia.
The role of multiple sclerosis subtype in microvascular decompression outcomes for patients with trigeminal neuralgia. Clinical neurology and neurosurgery Kalluri, A. L., So, R. J., Nair, S. K., Materi, J., Wang, D., Behera, N., Kornberg, M. D., Huang, J., Lim, M., Bettegowda, C., Xu, R. 2023; 233: 107967Abstract
OBJECTIVES: While patients with concomitant trigeminal neuralgia (TN) and multiple sclerosis (MS) are understood to experience a more intractable pain phenotype, whether TN pain outcomes differ by the presenting MS subtype is not well characterized. This study's objective is to compare post-operative pain and numbness outcomes following microvascular decompression (MVD) in TN patients with either relapsing-remitting MS (RRMS) or progressive MS.METHODS: We retrospectively reviewed all TN patients who underwent MVDs at our institution from 2007 to 2020. Of the 1044 patients reviewed, 45 (4.3%) patients with MS were identified. Patient demographics, procedural characteristics, and post-operative pain and numbness scores were recorded and compared. Factors associated with pain recurrence were assessed using survival analyses and multivariate regressions.RESULTS: Of the resulting 45 MS patients, 34 (75.6%) patients presented with the RRMS subtype, whereas 11 (24.4%) patients exhibited progressive MS. Using an adjusted multivariate ordinal regression, the subtype of MS was not significantly associated with the Barrow Neurological Institute (BNI) pain score at final follow-up. Using a Kaplan-Meier survival analysis and a multivariate Cox proportional hazards regression, respectively, RRMS was significantly associated with a shorter post-operative pain-free interval (p=0.04) as well as a greater risk for pain recurrence (p=0.02).CONCLUSIONS: Although the degree of pain at final follow-up may not differ, RRMS patients are at increased risk for pain recurrence following MVD for TN. These results align with a growing understanding that neuroinflammation may play a significant role in TN pain.
View details for DOI 10.1016/j.clineuro.2023.107967
View details for PubMedID 37703615