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Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma. Scientific reports Liu, W. W., Kinzy, T. G., Cooke Bailey, J. N., Xu, Z., Hysi, P., Wiggs, J. L. 2023; 13 (1): 15871

Abstract

Although glaucoma is a disease modulated by eye pressure, the mechanisms of pressure sensing in the eye are not well understood. Here, we investigated associations between mechanosensitive ion channel gene variants and primary open-angle glaucoma (POAG). Common (minor allele frequency?>?5%) single nucleotide polymorphisms located within the genomic regions of 20 mechanosensitive ion channel genes in the K2P, TMEM63, PIEZO and TRP channel families were assessed using genotype data from the NEIGHBORHOOD consortium of 3853 cases and 33,480 controls. Rare (minor allele frequency?

View details for DOI 10.1038/s41598-023-43072-3

View details for PubMedID 37741866

View details for PubMedCentralID PMC10517927