Abstract

The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference - held in Banff, Alberta - focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed the state-of-the-art of current histopathologic entities, serologic studies, and molecular practices, as well as novel applications of digital pathology with artificial intelligence, gene expression analysis, and quantitative image analysis of chest computerized tomography. Current states of need as well as prospective integration of the aforementioned tools and technologies for complete assessment of allograft injury and impact on lung transplant outcomes were discussed. Key conclusions from discussion were 1) recognition of limitations in current standard of care assessment of lung allograft dysfunction 2) agreement on the need for a consensus regarding the standardized approach to the collection and assessment of pathological data, inclusive of all lesions associated with graft outcome (e.g., non-rejection pathology), and 3) optimism regarding promising novel diagnostic modalities, especially minimally invasive, which should be integrated into large, prospective multicenter studies to further evaluate their utility in clinical practice for directing personalized therapies to improve graft outcomes.

View details for DOI 10.1016/j.ajt.2023.10.022

View details for PubMedID 37931751