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NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023. Journal of the National Comprehensive Cancer Network : JNCCN Zelenetz, A. D., Gordon, L. I., Abramson, J. S., Advani, R. H., Andreadis, B., Bartlett, N. L., Budde, L. E., Caimi, P. F., Chang, J. E., Christian, B., DeVos, S., Dholaria, B., Fayad, L. E., Habermann, T. M., Hamid, M. S., Hernandez-Ilizaliturri, F., Hu, B., Kaminski, M. S., Karimi, Y., Kelsey, C. R., King, R., Krivacic, S., LaCasce, A. S., Lim, M., Messmer, M., Narkhede, M., Rabinovitch, R., Ramakrishnan, P., Reid, E., Roberts, K. B., Saeed, H., Smith, S. D., Svoboda, J., Swinnen, L. J., Tuscano, J., Vose, J. M., Dwyer, M. A., Sundar, H. 2023; 21 (11): 1118-1131

Abstract

Novel targeted therapies (small molecule inhibitors, antibody-drug conjugates, and CD19-directed therapies) have changed the treatment landscape of relapsed/refractory B-cell lymphomas. Bruton's tyrosine kinase (BTK) inhibitors continue to evolve in the management of mantle cell lymphoma (MCL), in both the relapsed/refractory and the frontline setting. Anti-CD19 CAR T-cell therapies are now effective and approved treatment options for relapsed/refractory follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and MCL. Bispecific T-cell engagers represent a novel immunotherapeutic approach for relapsed FL and DLBCL after multiple lines of therapies, including prior CAR T-cell therapy. These NCCN Guideline Insights highlight the significant updates to the NCCN Guidelines for B-Cell Lymphomas for the treatment of FL, DLBCL, and MCL.

View details for DOI 10.6004/jnccn.2023.0057

View details for PubMedID 37935098