Abstract

BACKGROUND: When presenting for EGS care, older adults frequently experience increased risk of adverse outcomes owing to factors related to age ('geriatric vulnerability') and the social determinants of health unique to the places in which they live ('neighborhood vulnerability'). Little is known about how such factors collectively influence adverse outcomes. We sought to explore how the interaction between geriatric and neighborhood vulnerability influences EGS outcomes among older adults.METHODS: Older adults, =65 years, hospitalized with an AAST-defined EGS condition were identified in the 2016-2019, 2021 Florida State Inpatient Database. Latent variable models combined the influence of patient age, multimorbidity, and Hospital Frailty Risk Score into a single metric of "geriatric vulnerability." Variations in geriatric vulnerability were then compared across differences in "neighborhood vulnerability" as measured by variations in Area Deprivation Index, Social Vulnerability Index, and their corresponding subthemes (e.g. access to transportation).RESULTS: A total of 448,968 older adults were included. For patients living in the least vulnerable neighborhoods, increasing geriatric vulnerability resulted in up to six-times greater risk of death (30-day risk-adjusted HR[95%CI]: 6.32[4.49-8.89]). The effect was more than doubled among patients living in the most vulnerable neighborhoods, where increasing geriatric vulnerability resulted in up to fifteen-times greater risk of death (30-day risk-adjusted HR[95%CI]: 15.12[12.57-18.19]). When restricted to racial/ethnic minority patients, the multiplicative effect was four-times as high, resulting in corresponding 30-day hazard ratios for mortality of 11.53(4.51-29.44) versus 40.67(22.73-72.78). Similar patterns were seen for death within 365 days.CONCLUSION: Both geriatric and neighborhood vulnerability have been shown to affect pre-hospital risk among older patients. The results of this study build on that work, presenting the first in-depth look at the powerful multiplicative interaction between these two factors. The results show that where a patient resides can fundamentally alter expected outcomes for EGS care such that otherwise less vulnerable patients become functionally equivalent to those who are, at baseline, more aged, more frail, and more sick.LEVEL OF EVIDENCE: Prognostic and Epidemiological; Level III.

View details for DOI 10.1097/TA.0000000000004191

View details for PubMedID 37962136