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Scalability and Sustainability of a Surgical Infection Prevention Program in Low-Income Environments. JAMA surgery Starr, N., Gebeyehu, N., Nofal, M. R., Forrester, J. A., Tesfaye, A., Mammo, T. N., Weiser, T. G., Amdie, D. A., Abreha, M., Alemu, M., Ally, S., Abdukadir, A. A., Assefa, G., Bedore, Y., Bekele, A., Berhanu, M., Alemu, S. B., Chimdesa, Z., Derbew, M., Fast, C., Fernandez, K., Kahsay, S., Kassahun, A., Kebede, H., Kitesa, G., Koritsanszky, L., Lima, B., Mellese, B., Mengistu, M., Negash, S., Tara, M., Taye, S., Torgeson, K., Tsehaye, M., Tiruneh, A., Stave, K. 2023


Surgical infections are a major cause of perioperative morbidity and mortality, particularly in low-resource settings. Clean Cut, a 6-month quality improvement program developed by the global nonprofit organization Lifebox, has demonstrated improvements in postoperative infectious complications. However, the pilot program required intense external programmatic and resource support.To examine the improvement in adherence to infection prevention and control standards and rates of postoperative infections in hospitals in the Clean Cut program after implementation strategies were updated and program execution was refined.This cohort study evaluated and refined the Clean Cut implementation strategy to enhance scalability based on a qualitative study of its pilot phase, including formalizing programmatic and educational materials, building an automated data entry and analysis platform, and reorganizing hospital-based team composition. Clean Cut was introduced from January 1, 2019, to February 28, 2022, in 7 Ethiopian hospitals that had not previously participated in the program. Prospective data initiated on arrival in the operating room were collected, and patients were followed up through hospital discharge and with 30-day follow-up telephone calls.Implementation of the refined Clean Cut program.The primary outcome was surgical site infection (SSI); secondary outcomes were adherence to 6 infection prevention standards, mortality, hospital length of stay, and other infectious complications.A total of 3364 patients (mean [SD] age, 26.5 [38.0] years; 2196 [65.3%] female) from 7 Ethiopian hospitals were studied (1575 at baseline and 1789 after intervention). After controlling for confounders, the relative risk of SSIs was reduced by 34.0% after program implementation (relative risk, 0.66; 95% CI, 0.54-0.81; P?

View details for DOI 10.1001/jamasurg.2023.6033

View details for PubMedID 38019510