Abstract

Anorexia Nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. The current evidence supports the use of Family-Based Treatment (FBT), but recovery rates are about 40%. Improving treatment outcomes among adolescents will save lives, improve health, and prevent chronicity. This study examined the relative efficacy of adding Intensive Parental Coaching (IPC) to standard FBT for those who do not respond by weight gain of 2.4 kg by session 4, a clinical predictor of outcome at the end of treatment (EOT), to improve remission rates (>94% of expected mean body mass index (mBMI)).107 adolescents and their families were recruited, of whom 69 failed to respond early and were randomized to continue with standard FBT or to receive 3 sessions of IPC. Participants were adolescents with DSM-5 AN between the ages of 12-18 years recruited from across the US; 6.5% were male participants and 11% were Hispanic.Main outcomes were mBMI >94% expected for age, height, and sex. Secondary outcomes include change in eating-related cognitions. Adding IPC to early non-responders did not improve outcomes except for those whose parents demonstrated low parental self-efficacy at baseline (moderator). Early weight gain of 2.4kg by session 4 was replicated as a predictor of end of treatment remission.Parental self-efficacy (PSE) moderates IPC as an adaptive treatment for adolescent AN. Baseline PSE assessment can be used to identify those families most likely to benefit from adding IPC to FBT. Future studies should consider earlier interventions to improve early response rates.

View details for DOI 10.1016/j.jaac.2023.10.012

View details for PubMedID 38142046