Abstract

BACKGROUND: This study aims to evaluate patient outcomes of simultaneous triple organ transplants, which may provide insight into optimal donor allocation while maximizing recipient benefit.METHODS: Triple organ transplants and their corollary dual organ transplants were identified using the United Network for Organ Sharing database. Triple organ transplants evaluated included heart-lung-kidney (n=12) and heart-liver-kidney (n=37). Heart-lung-kidney recipients were compared with heart-lung (n=325), lung-kidney (n=91), and heart-kidney (n=2022) groups. Heart-liver-kidney recipients were compared with heart-liver (n=451), liver-kidney (n=10422), and heart-kidney (n=2517) recipients. Patient survival outcomes were calculated using the Kaplan-Meier method and compared using log-rank tests.RESULTS: Patients undergoing triple organ transplants showed similar 10-year survival as their corresponding dual organ transplant cohorts. Patient survival estimate at 10 years for the heart-lung-kidney group was 45%, with no statistically significant difference in survival when compared with dual organ groups (P=.16). Survival estimates at 10 years for the heart-liver-kidney group was 49%, with no statistically significant difference in survival when compared with dual organ groups (P=.06).CONCLUSION: Despite the surgical burden of adding a third organ transplant, heart-liver-kidney and heart-lung-kidney have similar survival outcomes to dual organ equivalents and represent a reasonable allocation option in well-selected patients.

View details for DOI 10.1016/j.transproceed.2023.11.029

View details for PubMedID 38195284