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The aMAP score predicts long-term outcomes after resection of hepatocellular carcinoma: a multi-institutional analysis. HPB : the official journal of the International Hepato Pancreato Biliary Association Tsilimigras, D. I., Endo, Y., Ratti, F., Marques, H. P., Cauchy, F., Lam, V., Poultsides, G. A., Popescu, I., Alexandrescu, S., Martel, G., Kitago, M., Guglielmi, A., Hugh, T., Aldrighetti, L., Gleisner, A., Shen, F., Endo, I., Pawlik, T. M. 2024

Abstract

BACKGROUND: The aMAP score is a proposed model to predict the development of hepatocellular carcinoma (HCC) among high-risk patients with chronic hepatitis. The role of the aMAP score to predict long-term survival among patients following resection of HCC has not been determined.METHODS: Patients undergoing resection for HCC between 2000 and 2020 were identified using a multi-institutional database. The impact of the aMAP score on long-term outcomes following HCC resection was assessed.RESULTS: Among 1377 patients undergoing resection for HCC, a total of 972 (70.6%) patients had a low aMAP score (=63), whereas 405 (29.4%) individuals had a high aMAP score (=64). aMAP score was associated with 5-year OS in the entire cohort (low vs high aMAP score:66.5% vs. 54.3%, p<0.001). aMAP score predicted 5-year OS following resection among patients with HBV-HCC (low vs. high aMAP:68.8% vs. 55.6%, p=0.01) and NASH/other-HCC (64.7% vs. 53.7, p=0.04). aMAP score could sub-stratify 5-year OS among patients undergoing HCC resection within (low vs. high aMAP:81.5% vs. 67.4%, p<0.001) and beyond (55.9% vs. 38.8%, p<0.001) Milan criteria.DISCUSSION: The aMAP score predicted postoperative outcomes following resection of HCC within and beyond Milan criteria. Apart from a surveillance tool, the aMAP score can also be used as a prognostic tool among patients undergoing resection of HCC.

View details for DOI 10.1016/j.hpb.2024.01.001

View details for PubMedID 38218690