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Sequential Treatment Failure With Aztreonam-Ceftazidime-Avibactam Followed by Cefiderocol Due to Preexisting and Acquired Mechanisms in a New Delhi Metallo-ß-lactamase-Producing Escherichia coli Causing Fatal Bloodstream Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Senchyna, F., Murugesan, K., Rotunno, W., Nadimpalli, S. S., Deresinski, S., Banaei, N. 2024

Abstract

We report a fatal case of New Delhi metallo-ß-lactamase (NDM)-producing Escherichia coli in a bacteremic patient with sequential failure of aztreonam plus ceftazidime-avibactam followed by cefiderocol. Acquired resistance was documented phenotypically and mediated through preexisting and acquired mutations. This case highlights the need to rethink optimal treatment for NDM-producing organisms.

View details for DOI 10.1093/cid/ciad759

View details for PubMedID 38289725