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Molecular International Prognostic Scoring System for Myelodysplastic Syndromes. NEJM evidence Bernard, E., Tuechler, H., Greenberg, P. L., Hasserjian, R. P., Arango Ossa, J. E., Nannya, Y., Devlin, S. M., Creignou, M., Pinel, P., Monnier, L., Gundem, G., Medina-Martinez, J. S., Domenico, D., Jädersten, M., Germing, U., Sanz, G., van de Loosdrecht, A. A., Kosmider, O., Follo, M. Y., Thol, F., Zamora, L., Pinheiro, R. F., Pellagatti, A., Elias, H. K., Haase, D., Ganster, C., Ades, L., Tobiasson, M., Palomo, L., Della Porta, M. G., Takaori-Kondo, A., Ishikawa, T., Chiba, S., Kasahara, S., Miyazaki, Y., Viale, A., Huberman, K., Fenaux, P., Belickova, M., Savona, M. R., Klimek, V. M., Santos, F. P., Boultwood, J., Kotsianidis, I., Santini, V., Solé, F., Platzbecker, U., Heuser, M., Valent, P., Ohyashiki, K., Finelli, C., Voso, M. T., Shih, L. Y., Fontenay, M., Jansen, J. H., Cervera, J., Gattermann, N., Ebert, B. L., Bejar, R., Malcovati, L., Cazzola, M., Ogawa, S., Hellström-Lindberg, E., Papaemmanuil, E. 2022; 1 (7): EVIDoa2200008

Abstract

MDS Molecular International Prognostic Scoring SystemSamples from over 2500 patients with MDS were profiled for gene mutations and used to develop the International Prognostic Scoring System-Molecular (IPSS-M). TP53multihit, FLT3 mutations, and MLLPTD were identified as top genetic predictors of adverse outcomes. IPSS-M improves prognostic discrimination across all clinical end points versus prior versions.

View details for DOI 10.1056/EVIDoa2200008

View details for PubMedID 38319256