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Consistency of Signal Intensity and T2*in Frozen Ex Vivo Heart Muscle, Kidney, and Liver Tissue

Consistency of Signal Intensity and T2*in Frozen Ex Vivo Heart Muscle, Kidney, and Liver Tissue JOURNAL OF MAGNETIC RESONANCE IMAGING Kaye, E. A., Josan, S., Lu, A., Rosenberg, J., Daniel, B. L., Pauly, K. B. 2010; 31 (3): 719-724

Abstract

To investigate tissue dependence of the MRI-based thermometry in frozen tissue by quantification and comparison of signal intensity and T2* of ex vivo frozen tissue of three different types: heart muscle, kidney, and liver.Tissue samples were frozen and imaged on a 0.5 Tesla MRI scanner with ultrashort echo time (UTE) sequence. Signal intensity and T2* were determined as the temperature of the tissue samples was decreased from room temperature to approximately -40 degrees C. Statistical analysis was performed for (-20 degrees C, -5 degrees C) temperature interval.The findings of this study demonstrate that signal intensity and T2* are consistent across three types of tissue for (-20 degrees C, -5 degrees C) temperature interval.Both parameters can be used to calculate a single temperature calibration curve for all three types of tissue and potentially in the future serve as a foundation for tissue-independent MRI-based thermometry.

View details for DOI 10.1002/jmri.22029

View details for PubMedID 20187218