Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

See our updated masking policy »

Stanford Health Care

Interim Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged =18 Years - VISION and IVY Networks, September 2023-January 2024. MMWR. Morbidity and mortality weekly report DeCuir, J., Payne, A. B., Self, W. H., Rowley, E. A., Dascomb, K., DeSilva, M. B., Irving, S. A., Grannis, S. J., Ong, T. C., Klein, N. P., Weber, Z. A., Reese, S. E., Ball, S. W., Barron, M. A., Naleway, A. L., Dixon, B. E., Essien, I., Bride, D., Natarajan, K., Fireman, B., Shah, A. B., Okwuazi, E., Wiegand, R., Zhu, Y., Lauring, A. S., Martin, E. T., Gaglani, M., Peltan, I. D., Brown, S. M., Ginde, A. A., Mohr, N. M., Gibbs, K. W., Hager, D. N., Prekker, M., Mohamed, A., Srinivasan, V., Steingrub, J. S., Khan, A., Busse, L. W., Duggal, A., Wilson, J. G., Chang, S. Y., Mallow, C., Kwon, J. H., Exline, M. C., Columbus, C., Vaughn, I. A., Safdar, B., Mosier, J. M., Harris, E. S., Casey, J. D., Chappell, J. D., Grijalva, C. G., Swan, S. A., Johnson, C., Lewis, N. M., Ellington, S., Adams, K., Tenforde, M. W., Paden, C. R., Dawood, F. S., Fleming-Dutra, K. E., Surie, D., Link-Gelles, R., CDC COVID-19 Vaccine Effectiveness Collaborators, Ghamande, S., Gottlieb, R., McNeal, T., Raver, C., Bender, W., Fletcher, L., Heaton, P., Kane, S., McEvoy, C., Thapa, S., Vazquez-Benitez, G., Frosch, A., Lamerato, L. E., Ramesh, M., Arnofer, J., Ali, H., Hopkins, J., Crane, B., Dandamudi, P., Goddard, K., Hansen, J., Timbol, J., Zerbo, O., Allen, K., Duszynski, T., Fadel, W., Rogerson, C., Qadir, N., Chavez, C., Doyle, B., Mayer, D., Rao, S., Rivas, C., Johnson, N. J., Baughman, A., Lwin, C. T., Rhoads, J. P., Womack, K. N., Dunne, M., Ciesla, A., Mak, J., Najdowski, M., Ray, C. 2024; 73 (8): 180-188

Abstract

In September 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (monovalent XBB.1.5) COVID-19 vaccination for all persons aged =6 months to prevent COVID-19, including severe disease. However, few estimates of updated vaccine effectiveness (VE) against medically attended illness are available. This analysis evaluated VE of an updated COVID-19 vaccine dose against COVID-19-associated emergency department (ED) or urgent care (UC) encounters and hospitalization among immunocompetent adults aged =18 years during September 2023-January 2024 using a test-negative, case-control design with data from two CDC VE networks. VE against COVID-19-associated ED/UC encounters was 51% (95% CI = 47%-54%) during the first 7-59 days after an updated dose and 39% (95% CI = 33%-45%) during the 60-119 days after an updated dose. VE estimates against COVID-19-associated hospitalization from two CDC VE networks were 52% (95% CI = 47%-57%) and 43% (95% CI = 27%-56%), with a median interval from updated dose of 42 and 47 days, respectively. Updated COVID-19 vaccine provided increased protection against COVID-19-associated ED/UC encounters and hospitalization among immunocompetent adults. These results support CDC recommendations for updated 2023-2024 COVID-19 vaccination. All persons aged =6 months should receive updated 2023-2024 COVID-19 vaccine.

View details for DOI 10.15585/mmwr.mm7308a5

View details for PubMedID 38421945