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High Throughput Plasma Proteomics and Risk of Heart Failure and Frailty in Late Life.

High Throughput Plasma Proteomics and Risk of Heart Failure and Frailty in Late Life. JAMA cardiology Ramonfaur, D., Buckley, L. F., Arthur, V., Yang, Y., Claggett, B. L., Ndumele, C. E., Walker, K. A., Austin, T., Odden, M. C., Floyd, J. S., Sanders-van Wijk, S., Njoroge, J., Kizer, J. R., Kitzman, D., Konety, S. H., Schrack, J., Liu, F., Windham, B. G., Palta, P., Coresh, J., Yu, B., Shah, A. M. 2024

Abstract

Heart failure (HF) and frailty frequently coexist and may share a common pathobiology, although the underlying mechanisms remain unclear. Understanding these mechanisms may provide guidance for preventing and treating both conditions.To identify shared pathways between incident HF and frailty in late life using large-scale proteomics.In this cohort study, 4877 aptamers (Somascan v4) were measured among participants in the community-based longitudinal Atherosclerosis Risk In Communities (ARIC) cohort study at visit 3 (V3; 1993-1995; n?=?10?638) and at visit 5 (V5; 2011-2013; n?=?3908). Analyses were externally replicated among 3189 participants in the Cardiovascular Health Study (CHS). Data analysis was conducted from February 2022 to June 2023.Protein aptamers, measured at study V3 and V5.Outcomes assessed included incident HF hospitalization after V3 and after V5, prevalent frailty at V5, and incident frailty between V5 and visit 6 (V6; 2016-2017; n?=?4131). Frailty was assessed using the Fried criteria. Analyses were adjusted for age, gender, race, field center, hypertension, diabetes, smoking status, body mass index, estimated glomerular filtration rate, prevalent coronary heart disease, prevalent atrial fibrillation, and history of myocardial infarction. Mendelian randomization (MR) analysis was performed to assess potential causal effects of candidate proteins on HF and frailty.A total of 4877 protein aptamers were measured among 10?638 participants at V3 (mean [SD] age, 60 [6] years; 4886 [46%] men). Overall, 286 proteins were associated with incident HF after V3 (822 events; P?

View details for DOI 10.1001/jamacardio.2024.1178

View details for PubMedID 38809565