African Mitochondrial DNA Subhaplogroups and Peripheral Neuropathy during Antiretroviral Therapy JOURNAL OF INFECTIOUS DISEASES Canter, J. A., Robbins, G. K., Selph, D., Clifford, D. B., Kallianpur, A. R., Shafer, R., Levy, S., Murdock, D. G., Ritchie, M. D., Haas, D. W., Hulgan, T. 2010; 201 (11): 1703-1707


Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we sequenced mtDNA of participants from AIDS Clinical Trials Group study 384. Of 156 non-Hispanic black persons with genomic data, 51 (33%) developed peripheral neuropathy. In a multivariate model, African mtDNA subhaplogroup L1c was an independent predictor of peripheral neuropathy (odds ratio, 3.7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity.

View details for DOI 10.1086/652419

View details for Web of Science ID 000277176200014

View details for PubMedID 20402593

View details for PubMedCentralID PMC2862090