Prediction of glycosaminoglycan content in human cartilage by age, T1 rho and T2 MRI OSTEOARTHRITIS AND CARTILAGE Keenan, K. E., Besier, T. F., Pauly, J. M., Han, E., Rosenberg, J., Smith, R. L., Delp, S. L., Beaupre, G. S., Gold, G. E. 2011; 19 (2): 171-179


A relationship between T1? relaxation time and glycosaminoglycan (GAG) content has been demonstrated in chemically degraded bovine cartilage, but has not been demonstrated with quantitative biochemistry in human cartilage. A relationship has also been established between T2 relaxation time in cartilage and osteoarthritis (OA) severity. We hypothesized that T1? relaxation time would be associated with GAG content in human cartilage with normal T2 relaxation times.T2 relaxation time, T1? relaxation time, and glycosaminoglycan as a percentage of wet weight (sGAG) were measured for top and bottom regions at 7 anatomical locations in 21 human cadaver patellae. For our analysis, T2 relaxation time was classified as normal or elevated based on a threshold defined by the mean plus one standard deviation of the T2 relaxation time for all samples.In the normal T2 relaxation time subset, T1? relaxation time correlated with sGAG content in the full-thickness and bottom regions, but only marginally in the top region alone. sGAG content decreased significantly with age in all regions.In the subset of cartilage specimens with normal T2 relaxation time, T1? relaxation time was inversely associated with sGAG content, as hypothesized. A predictive model, which accounts for T2 relaxation time and the effects of age, might be able to determine longitudinal trends in GAG content in the same person based on T1? relaxation time maps.

View details for DOI 10.1016/j.joca.2010.11.009

View details for Web of Science ID 000287470600005

View details for PubMedID 21112409

View details for PubMedCentralID PMC3041640