Autologous Stem Cell Rescue for Primary Amyloidosis

Trial ID or NCT#

NCT00186407

Status

not recruiting iconNOT RECRUITING

Purpose

To evaluate the role of high dose therapy and autologous hematopoietic cell transplant for amyloidosis.

Official Title

High Dose Chemotherapy and Autologous Stem Cell Rescue for Primary Amyloidosis

Eligibility Criteria

Ages Eligible for Study: 18 Years to 75 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. 1. Primary amyloidosis
  2. 2. Age \< 75 years.
  3. 3. Patients must have their pathology reviewed and the diagnosis confirmed at Stanford University Medical Center.
  4. 4. Patients who have undergone bone marrow transplantation previously will not be eligible.
  5. 5. Patients must have a Karnofsky performance status greater than 70%.
  6. 6. Patients must have a serum creatinine less than 2 mg/dl or creatinine clearance greater than 30 ml/min, bilirubin less than 2 mg/dl, transaminases less than two times normal, left ventricular ejection fraction \>45% on echocardiography, cardiac index \> 1.8 liters/min/m\^2 and pulmonary function tests demonstrating FEV1 and DLCO \> 60%.
  7. 7. Patients must be HIV negative.
  8. 8. Pregnant or lactating women will not be eligible to participate.
  9. 9. Patients must provide signed informed consent.
  10. 10. Patients with multiple myeloma and amyloid are eligible.
Exclusion Criteria:
  1. 1. prior blood or marrow transplant
View All Criteria
Show Less

Investigator(s)

Sally Arai
Sally Arai
Blood and marrow transplant specialist, Hematologist, Blood and marrow transplant specialist
Associate Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Robert Lowsky
Robert Lowsky
Blood and marrow transplant specialist, Hematologist, Blood and marrow transplant specialist
Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Robert Negrin
Robert Negrin
Blood and marrow transplant specialist, Hematologist, Blood and marrow transplant specialist
Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Laura Johnston
Laura Johnston
Blood and marrow transplant specialist, Blood and marrow transplant specialist, Medical oncologist, Hematologist
Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy), Emerita

Contact us to find out if this trial is right for you.

Contact

BMT Referrals
6507230822

View on ClinicalTrials.gov